Endocrine Abstracts

The Daily Tolerable Intake (DTI) was reduced by BPA (bisphenol A) 100,000 fold. This is an unprecedented action to protect consumers and the environment from the most commonly used plasticizer. However, one problem identified was the fact that regrettable substitutes, such as BPS and BPF, were not included in the recommendation. There will be a fight to ensure that this passes into the European legislation. In the meantime, BP-B (,4’-(1-methylpropylidene) bisphenol (a sub...

During vertebrate evolution thyroid hormone acquired multiple roles in development, especially brain development. Examples include promotion of myelination thereby increasing speed of neuronal transmission, as well as modulation of neuronal differentiation, as exemplified by the exquisite sensitivity of the Purkinje neuron to thyroid hormone deficiency. Research in the last 15 years has demonstrated that early development, the first trimester of pregnancy in humans, is an unex...

Transthyretin (TTR) distributes thyroxine in the cerebrospinal fluid of mammals. Choroid plexus epithelial cells produce and secrete TTR, and were long recognized as the only CNS source of TTR. However, research over the last years has reported neuronal-specific expression as well, but without a clear function. Recently, we found Ttr transcripts in cells of the adult mouse subventricular zone (SVZ), the largest neural stem cell (NSC) region, but the protein was undetectable. W...

Phthalate exposure is associated with thyroid function during pregnancy through a novel pathway as a hCG disruptor.Objectives: hCG stimulates thyroid function in pregnancy and phthalates are known thyroid disruptors. We investigated if phthalate exposure could act as a thyroid disruptor through affecting hCG.Methods: This study was embedded in the prospective Swedish Environmental Longitudinal, Mother and child, Asthma and allergy ...